Vincristine - An Anti-neoplastic drug

Vincristine is an anti-tumor vinca alkaloid isolated from Vinca Rosea. Vincristine is being isolated from Cantharanthus roseus plant

Chemical formula of Vinca Alkaloid : C46H56N4O10

It is a Mitotic inhibitor drug
It is a cell cycle phase specific drug
It is active only in M-Phase
It bind to tubuline and interfere with mitotic spindle formation and thus segregation of chromosomes in metaphase is arrested.

It given on strict Intra venous route
Within 15-30 minute after injection, over 90% of the drug is distributed from blood into tissue.
The liver is the major excretory organ of vincristine in Human and Animals
The metabolism of vinca alkaloids has been shown to be mediated by hepatic chromosome P-450 isoenzymes in the CYP 3A subfamily.
About 80% of injected dose of vincristine sulphate excrete in faeces and 10-20% excreted in urine.

It is used either alone or in combination with other anti-neoplastic drugs for treatment of following condition:-

In CTVT, Vincristine sulphate given at 0.025mg/kg dose.

Vincristine sulphate given once in a week for continuous 4 week

Surface area = Body weight⁰∙⁶⁷ × K/10⁴

Here K=10 in cats while K=10.1 in dogs

Linkage into surrounding tissue during I/V administration of vincristine sulphate injection may cause considerable irritation. If extravasation occur the injection should be discontinuous immediately.
Affect hepatic function that is why it is not given in the patient which suffer from hepatic diseases.
Alopecia
It affect renal function that leads to Dysuria or Urinary retention
It affects on skin and produce anaphylactic reaction. Also produce urticarial lesion.
Leukopenia
Adrenal disorder
Hypotension with dehydration
Neurological disorder
Oedema
Blindness

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